Mission & Vision
- The program addresses the production of integrated knowledge about key elements of microbial pathogenicity in order to contribute to global protection from infections. The combat against infectious diseases is based not only on Prevention but also on Protection (thus our use of the terms Protective Medicine). The diversity of human microbiota, that is so relevant for health, reflects the complexity of its interactions and suggests the existence of a delicate balance between the levels that determine adaptations of mutualism, commensalism and parasitism.
- By using post-genomic tools we will globally explore circuits involved in cell-environment and cell-cell communications, both inter- and intra-specific, as well as the reprogramming of intracellular signalling and metabolism in response to those interactions. The common program focuses on cellular microbes (bacteria and fungi) and articulates three levels of study:
- Microbial communities of intestinal microbiota
- Host-pathogen interactions:
- Mechanisms that determine intercellular communication and activate signalling
- This proposal contributes to the objectives of the call for proposals of research programs in Biomedicine, especially from the point of view of advancing in fundamental knowledge that can be translated into results for the health system. The program is based on the experience of a previous research program namely DeReMicrobiana-CM (Development and Reprogramming of Microbial Systems; S-Sal-0246-2006).
- The groups experienced a very motivating collaboration, one of the main achievements being their contribution to the establishment of an institute of medical research in the Ramón y Cajal Hospital (IRYCIS).